Successful aging: insights from proteome analyses of healthy centenarians
نویسندگان
چکیده
منابع مشابه
Centenarians as a model for healthy aging.
For over 10 years we have studied centenarians as a model to address the biological basis of aging and longevity, with particular attention to immunology and genetics. The most important findings can be summarized as follows. (i) Human immunosenescence represents a complex remodelling, whereby clonotypical immunity deteriorates, while ancestral, innate immunity is largely preserved. (ii) Contin...
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Human life expectancy has nearly doubled in the past century due, in part, to social and economic development, and a wide range of new medical technologies and treatments. As the number of elderly increase it becomes of vital importance to understand what factors contribute to healthy aging. Human longevity is a complex process that is affected by both environmental and genetic factors and inte...
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As the aging population expands rapidly worldwide, it has become increasingly important to identify factors that offer means to promote healthy aging. It is well documented that advancing age is associated with increased body fat and blunted insulin action. Centenarians, who are the best model of successful aging, are a unique exception to this phenomenon. Increasing evidence has documented the...
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With advancing age, an increasing number of healthy individuals have laboratory signs of heightened coagulation enzyme activity. Such biochemical hypercoagulability might be the basis of either the increased thrombotic tendency occurring with age or a harmless manifestation of this process. To see whether these alterations are also present in the very elderly who had aged successfully, 25 healt...
متن کاملSuccessful aging among Chinese near-centenarians and centenarians in Hong Kong: a multidimensional and interdisciplinary approach.
OBJECTIVES This study applied a multidimensional model on a continuum to examine successful aging (SA) and investigated whether SA is associated with biomedical and psychosocial-demographic factors among Hong Kong Chinese near-centenarians and centenarians. METHOD A cross-sectional data analysis was performed on a geographically representative sample of 120 near-centenarians and centenarians ...
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ژورنال
عنوان ژورنال: Aging
سال: 2020
ISSN: 1945-4589
DOI: 10.18632/aging.102826